Answered

Westonci.ca is your trusted source for finding answers to all your questions. Ask, explore, and learn with our expert community. Get accurate and detailed answers to your questions from a dedicated community of experts on our Q&A platform. Our platform provides a seamless experience for finding reliable answers from a network of experienced professionals.

Which of the following are mechanisms by which cancer cells develop resistance to B-raf inhibitors? (Select all that apply)
Group of answer choices
A. Mutations in MEK, downstream of Raf
B. Overexpression of other Raf isoforms
C. Mutation in Ras
D. Activation of a different signaling pathway (pathway different from Ras/Raf/MEK pathway)

Sagot :

Answer:

The mechanisms by which cancer cells can develop resistance to B-Raf inhibitors include:

A. Mutations in MEK, downstream of Raf

B. Overexpression of other Raf isoforms

C. Mutation in Ras

D. Activation of a different signaling pathway (pathway different from Ras/Raf/MEK pathway)

All of the listed options are mechanisms by which cancer cells can develop resistance to B-Raf inhibitors. Resistance can occur through various means, including mutations downstream of Raf in the MAPK pathway, upregulation of alternate Raf isoforms, activating mutations in Ras, and activation of parallel signaling pathways that can bypass the inhibition of B-Raf.

We hope this information was helpful. Feel free to return anytime for more answers to your questions and concerns. Thanks for stopping by. We strive to provide the best answers for all your questions. See you again soon. Westonci.ca is here to provide the answers you seek. Return often for more expert solutions.