Which of the following molecules would accumulate if too little acetate flows into the citric acid cycle? a) ADP b) ATP c) glucose d) FADH2 e) NADH

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06-12-2022
Biology

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Which of the following molecules would accumulate if too little acetate flows into the citric acid cycle? a) ADP b) ATP c) glucose d) FADH2 e) NADH

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kumarkrishna kumarkrishna · Answer 1 · 2022-12-08T12:41:05-05:00

The correct option is A) ADP. One adenine, one sugar, and two phosphates make up the biological molecule known as adenosine diphosphate (ADP).

Citrate synthase is inhibited by ATP, which is the result of the citric acid cycle. ADP (adenosine diphosphate), which is produced when ATP is broken down from ADP, acts as an allosteric activator of the enzyme. As a result, when the cell has a high level of ATP, the cycle's rate slows down. Acetyl-CoA, an important source of carbon for the citric acid cycle, can come from either glucose or fatty acids, but the latter source—pyruvate—provides the majority of acetyl-CoA. The metabolic conversion of pyruvate to acetyl-CoA is facilitated by the pyruvate dehydrogenase complex (PDC). Three protein subunits make up this complex, each of which has a distinct enzymatic function and needs five cofactors in total. [1] The complex can be highly controlled due to the need for cofactors and the distinct functions of each component; in fact, the pyruvate dehydrogenase complex is a crucial regulator of glucose metabolism.

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