chromatin remodeling by the swi/snf complex requires hydrolysis of atp. what purpose does this serve?

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05-12-2022
Biology

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chromatin remodeling by the swi/snf complex requires hydrolysis of atp. what purpose does this serve?

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kumarkrishna kumarkrishna · Answer 1 · 2022-12-07T11:58:45-05:00

It serves two main functions when DNA is wrapped around histones to form chromatin structure: first, it causes condensation of the long (many meters) DNA strand so that it can fit into the nucleus appropriately. Second, it prevents DNA from being transcribed continuously.

To begin gene expression, chromatin must first be unwrapped, a

process known as chromatin remodeling. It follows that chromatin remodeling is an essential step for regulating key physiological functions and preserving cellular homeostasis. Additionally, gene expression is inherently dependent on chromatin remodeling. The process, which requires ATP for energy, is nearly totally marked by the release of the TATA binding protein (TBP) from the somatic chromatin. An ISWI-containing remodeling factor is an essential component in this substantial chromatin remodeling in vitro. By relocating, assembling, mobilizing, and rearranging nucleosomes, ATP-dependent chromatin remodeling complexes change the chromatin structure. Hence, The SWI/SNF chromatin remodeling complex performs crucial functions in DNA-based activities by facilitating chromatin access using the energy of ATP hydrolysis.

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