Inactivated vaccine. An inactivated vaccination, also known as a killed vaccine, contains microorganisms that have been cultivated in culture and subsequently destroyed in order to lose their ability to cause illness. Live vaccinations, on the other hand, employ germs that are still living (but are almost always attenuated, that is, weakened). In order to limit pathogen infectivity and hence avoid infection from the vaccination, pathogens for inactivated vaccines are cultivated under carefully regulated conditions and are destroyed.
Cholera, plague, and typhoid vaccines were initially created in the late 1800s and early 1900s.
There are inactivated vaccinations available now for several infections, including polio, rabies, hepatitis A, pertussis, influenza, and polio (IPV).
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