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A bacterium is transferred from the nutrient rich to a nutrient poor environment, or starts producing Alarmones and Stringent respone regulatory mechanism gets activated.
Bacteria regulate the degradation of messenger RNAs (mRNAs), the molecules that sit between the expression of genes and the creation of proteins, in order to adapt to environmental changes. Although bacteria can survive at higher and lower temperatures than humans, they thrive in an environment that is warm, moist, protein-rich, and pH neutral or slightly acidic. An alarmone is an intracellular signal molecule that is produced in bacteria, chloroplasts, and a slim minority of archaea reacting to harsh environmental factors. They regulate the gene expression at transcription level. The stringent response (SR), which regulates adaptation to nutritional deprivation, is a well conserved bacterial stress response that is triggered by a variety of hunger and stress cues.
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