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Pyruvate dehydrogenase is regulated by feedback inhibition and covalent modification. Which molecules inhibit the pyruvate dehydrogenase complex?

Sagot :

ADP, NAD+, CoA-SH, and pyruvate are the molecules that inhibit the pyruvate dehydrogenase complex.

What is pyruvate dehydrogenase complex?

PDC3 triggers the oxidative decarboxylation of pyruvate, resulting in the creation of acetyl-CoA, CO2, and NADH.

The PDC plays a crucial role in the oxidation of glucose by connecting the glycolytic pathway to the tricarboxylic acid cycle's oxidative pathway.

ADP, NAD+, CoA-SH, and pyruvate all inhibit it. PDK prevents glycolysis from being coupled to GO by inhibiting its target enzyme PDH.

Thus, the answer is ADP, NAD+, CoA-SH, and pyruvate .

For more details regarding pyruvate dehydrogenase, visit:

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