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First used in 1821, which of the following trade routes connected Missouri with Mexico? a. the California Trail b. the Oregon Trail c. the Santa Fe Trail d. the Wilderness Trail

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First used in 1821, the Santa Fe Trail was an important trade route that connected Missouri with Mexico. 
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Answer:

First used in 1821, which of the following trade routes connected Missouri with Mexico? a. the California Trail b. the Oregon Trail c. the Santa Fe Trail d. the Wilderness Trail

Explanation:

The Santa Fe Trail was opened in 1821, was a famous route of transport of the XIX century that ran through the center of North America, connecting the cities of Independence (now Missouri) and Santa Fe (today New Mexico).

The answer is: c. The Santa Fe Trail.

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