Koshland, Nemethy and Filmer, proposed a model for the binding of a ligand to a dimeric protein, where the following interaction constants were introduced: KTT: KRT, KRR. Give the relationships between these constants as well as Kb1 and Kb2 during no cooperativity, positive homotropic cooperativity and negative homotropic cooperativity.

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10-06-2024
Biology

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Koshland, Nemethy and Filmer, proposed a model for the binding of a ligand to a dimeric protein, where the following interaction constants were introduced: KTT: KRT, KRR. Give the relationships between these constants as well as Kb1 and Kb2 during no cooperativity, positive homotropic cooperativity and negative homotropic cooperativity.

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